A couple may have a child to provide stem cells for another child. They may also use preimplantation testing—even, troubling though it is, prenatal testing and selective abortion—to ensure a close tissue match.

Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

JOHN CORCORAN AND WAGNER SANZ, Disbelief Logic Complements Belief Logic. Philosophy, University at Buffalo, Buffalo, NY 14260-4150 USA E-mail: [email protected] Filosofia, Universidade Federal de Goiás, Goiás, GO 74001-970 Brazil E-mail: [email protected] -/- Consider two doxastic states belief and disbelief. Belief is taking a proposition to be true and disbelief taking it to be false. Judging also dichotomizes: accepting a proposition results in belief and rejecting in disbelief. Stating follows suit: asserting a proposition conveys belief and denying conveys disbelief. (...) Traditional logic implicitly focused on logical relations and processes needed in expanding and organizing systems of beliefs. Deducing a conclusion from beliefs results in belief of the conclusion. Deduction presupposes consequence: one proposition is a consequence of a set of a propositions if the latter logically implies the former. The role of consequence depends on its being truth-preserving: every consequence of a set of truths is true. This paper, which builds on previous work by the second author, explores roles of logic in expanding and organizing systems of disbeliefs. Aducing a conclusion from disbeliefs results in disbelief of the conclusion. Aduction presupposes contrequence: one proposition is a contrequence of a set of propositions if the set of negations or contradictory opposites of the latter logically implies that of the former. The role of contrequence depends on its being falsity-preserving: every contrequence of a set of falsehoods is false. A system of aductions that includes, for every contrequence of a given set, an aduction of the contrequence from the set is said to be complete. Historical and philosophical discussion is illustrated and enriched by presenting complete systems of aductions constructed by the second author. One such, a natural aduction system for Aristotelian categorical propositions, is based on a natural deduction system attributed to Aristotle by the first author and others. ADDED NOTE: Wagner Sanz reconstructed Aristotle’s logic the way it would have been had Aristole focused on constructing “anti-sciences” instead of sciences: more generally, on systems of disbeliefs. (shrink)

Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Successful preimplantation genetic diagnosis (PGD) to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization (IVF) to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that (...) the parents will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing” (rather than to avoid a sex-linked disorder), PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

We propose an analogy between optical holography and neural behavior as a hypothesis about the physical mechanisms of neural reuse. Specifically, parameters in optical holography (frequency, amplitude, and phase of the reference beam) may provide useful analogues for understanding the role of different parameters in determining the behavior of neurons (e.g., frequency, amplitude, and phase of spiking behavior).

O positivismo jurídico é predominantemente ensinado e aplicado há décadas por profissionais da área jurídica brasileira, geralmente com referência à construção teórica de Hans Kelsen (1881-1973), deixando à margem muitos outros estudos que oferecem importantes formulações e conceitos para a compreensão do Direito contemporâneo. Este artigo se junta a algumas poucas pesquisas sobre outros referenciais teóricos acerca do positivismo jurídico, analisando a regra de reconhecimento no pensamento teórico de Herbert Hart (1907-1992), apresentando-a como incremento e superação da teoria imperativista de (...) John Austin (1790-1859). A partir de pesquisa bibliográfica, mostramos que, em Hart, a regra de reconhecimento (modalidade de regra secundária) apresenta-se indispensável para a certeza necessária ao Direito, bem como para aferir a validade do sistema jurídico. (shrink)

Evidentiary propositions E 1 and E 2, each p-positively relevant to some hypothesis H, are mutually corroborating if p > p, i = 1, 2. Failures of such mutual corroboration are instances of what may be called the corroboration paradox. This paper assesses two rather different analyses of the corroboration paradox due, respectively, to John Pollock and Jonathan Cohen. Pollock invokes a particular embodiment of the principle of insufficient reason to argue that instances of the corroboration paradox are of (...) negligible probability, and that it is therefore defeasibly reasonable to assume that items of evidence positively relevant to some hypothesis are mutually corroborating. Taking a different approach, Cohen seeks to identify supplementary conditions that are sufficient to ensure that such items of evidence will be mutually corroborating, and claims to have identified conditions which account for most cases of mutual corroboration. Combining a proposed common framework for the general study of paradoxes of positive relevance with a simulation experiment, we conclude that neither Pollock’s nor Cohen’s claims stand up to detailed scrutiny. I am quite prepared to be told…”oh, that is an extreme case: it could never really happen!” Now I have observed that this answer is always given instantly, with perfect confidence, and without any examination of the proposed case. It must therefore rest on some general principle: the mental process being something like this—“I have formed a theory. This case contradicts my theory. Therefore, this is an extreme case, and would never occur in practice.”Rev. Charles L. Dodgson. (shrink)

As a work of a scholarship it seems to me to compare favourably with the best books on the subject, including those by Marcus Singer and Onora Nell.' Prof.

In response to Charles Taylor's book "Sources of the Self: The Making of the Modern Identity," Becker defends the Western view of ethical conceptions based on our unique identity, reasoning, and historical heritage.

Aristotelian commenters have long noted an apparent contradiction between what Aristotle says in Posterior Analytics I.2 and Physics I.1 about how we obtain first principles of a science. At Posterior 71b35–72a6, Aristotle states that what is most universal (καθόλου) is better-known by nature and initially less-known to us, while the particular (καθ’ ἕκαστον) is initially better-known to us, but less-known by nature. At Physics 184a21-30, however, Aristotle states that we move from what is better-known to us, which is universal (καθόλου), (...) to what is better-known absolutely, which is particular (καθ’ ἕκαστον). This paper turns to two of Aristotle’s most notable medieval commentators—Albertus Magnus and Thomas Aquinas—to resolve this apparent contradiction. The key to Thomas and Albert’s solutions, we will argue, is a twofold distinction between a sense-perceptive and scientific universal, and the particulars as sensed individuals and as differentiating attributes. Our Synthetic treatment of these distinctions contributes to the ongoing scholarly effort to understand the Stagyrite’s complex theory of knowledge. (shrink)

Examines Arthur Schopenhauer's (1788-1860) conception of human agency and responsibility, his unique ethics of the morally virtuous character, and his assessment of life as fundamentally suffering. This title focuses on his contention that the human will and the human body cannot have a cause and effect relationship with each other.

This book presents a detailed fieldwork-based study of the ancient Indian religion of Jainism. Drawing on field research in northern Gujarat and on the study of both ancient Sanskrit and Prakrit and modern vernacular Jain religious literature, John Cort provides a rounded portrait of the religion as it is practiced today.

A mutual relation between God and the world provides a crucial distinction between panentheism and both classical theism and pantheism. Several proposals responding to Analytical Theology's challenge to distinguish panentheism from other forms of theism are considered and found inadequate. After defining mutual relation, conceptual evidence and the frequency of descriptions of panentheism that affirm a mutual relation between God and the world provide evidence that a mutual relation is crucial to distinguishing panentheism. Finally, benefits of recognizing a mutual relation (...) between God and the world as crucial to panentheism are described. (shrink)

Despite the growing debate about scholarly impact, an analysis of the onto-epistemic grammar underlying impact has remained absent. By taking a different analytical approach to examining impact, we interrogate the concept through the lens of decolonial thought. We offer an empathetic review of the impact scholarship and illuminate the limits of the modern imaginary that circumscribe critiques of impact in the literature, making visible the Eurocentric and provincial horizons of modern reason underlying these critiques and impact in general. Drawing on (...) Śūnyatā ontological perspective, we seek to articulate from modernity imaginary’s edges and suggest imagining and being otherwise. We argue that the question of scholarly impact is intimately structured by and connected to the modern subject’s desire for ontological security. (shrink)

The Division of Investigative Oversight within the U.S. Office of Research Integrity (ORI) is responsible for conducting oversight review of institutional inquiries and investigations of possible research misconduct. It is also responsible for determining whether Public Health Service findings of research misconduct are warranted. Although ORI findings rely primarily on the scope and quality of the institution’s analyses and determinations, ORI often has been able to strengthen the original findings by employing a variety of analytical methods, often computer based. Although (...) ORI does not conduct inquiries or investigations, it has broad authority to provide assistance to institutions at all stages of their reviews of allegations. This assistance can range from providing advice on best practices, to legal assistance, to suggestions for how best to investigate specific allegations. When asked, ORI can also conduct certain forensic analyses, such as a statistical examination of questioned digits or a simple examination of a questioned figure in Photoshop. ORI will not provide opinions or render judgment on such analyses while the institution is still conducting its investigation. Such analyses can be done without knowing much else about the case. (shrink)

This article explores the rhetoric, and mass mediation, of the national Holocaust Memorial Day commemoration ceremony, as broadcast on British television. I argue that the televised national ceremonies should be approached as an example of multi-genre epideictic rhetoric, working up meanings through a hybrid combination of genres, author/animators and modes. Epideictic rhetoric has often been depreciated as simply ceremonial ‘praise or blame’ speeches. However, given that the topics of praise/blame assume the existence of social norms, epideictic also acts to presuppose (...) and evoke common values, in general, and a collective recognition of shared social responsibilities, in particular. My methodology draws on the Discourse-Historical Approach to Critical Discourse Analysis, given, first, its central prominence in analysing argumentative strategies in discourse and, second, the ways it facilitates a reflexive ‘shuttling’ between text-discursive features, intertextual relations and wider contexts of society and history. Here, I examine how a catastrophic past is invoked in speech and evoked through image and music, in response to the demands that uncertainty of the future ‘places upon one’s conscience’. (shrink)

This paper argues that there is a need to move yet further than has already been suggested by some from the individual to the collective as a base for public health. A communitarian approach is one way to achieve this. This has the advantage of allowing not only the community’s voice to have a say in setting the values for public health but also more formally the development of a constitution on which public health might then be built. It also (...) sees public health as a social institution which can be valued in its own right. (shrink)

This article, taking a social semiotic approach, analyses two pieces of music written, shared and exalted by two pre-1945 European fascist movements – the German NSDAP and the British Union of Fascists. These movements, both political and cultural, employed mythologies of unity, common identity and purpose in order to elide the realities of social distinction and political–economic inequalities between bourgeois and proletarian groups in capitalist societies. Visually and inter-personally, the fascist cultural project communicated a machine-like certainty about a vision for (...) a new society based on discipline, conformity and the might of the nation. In this article, we are interested in the ways that these very same discourses are also communicated through sound and music in two songs: The Horst Wessel Lied and the BUF marching song, two songs that used the same melody. We analyse the discourses communicated by the semiotic choices made in melody, arrangements, sound qualities, rhythms as well as in lyrics. The article first identifies some of the underlying semiotic resources for meaning making in sound and then shows how these are used in order to communicate specific ideas, values and attitudes. (shrink)

The two best known objections to Kant's first defense of the duty of beneficence are examined and found to be fallacious. The first objection relies on the possibility of imagining an individual who would be willing for the maxim of nonbeneficence to be a universal law (but it fails to recognize that such an individual is not a rational person and thus not subject to morality at all); and the second objection, while granting the nonuniversalizability of the maxim of nonbeneficence, (...) puts forth the maxim of “occasional” benefit in place of the maxim of beneficence as an alternative to the maxim of nonbeneficence (but it fails to recognize that the maxim of “occasional” benefit is disqualified by Kant's first moral principle). (shrink)